Novel oligo-peptides in regulated high-fructose and high-fat induced type 2 diabetes in a murine model

People suffered from type 2 diabetes were change in eating habits in diet. Fructose consumption increase incidence of hepatic manifestation of metabolic syndrome including insulin resistance and diabetes mellitus. In recent years, small molecular oligopeptides were used in prevention and treatment of related diseases. In this study, chicken meat is a by-product of chicken essence processing was used to hydrolyze by microbes. An effected fraction was used to regulate type 2 diabetes in high fat and high-fructose administered murine model to increase insulin sensitivity and prevent type 2 diabetes by functional oligopeptides from chicken meat hydrolysate. The result indicated the effected fraction can reduced the inflammatory mediators including IFN-γ, IL-6 and MCP-1. Adiponectin and neuregulin-4 were the important adipokines involved in the regulation of insulin resistance and diabetes mellitus.  The peptides sequences were identified by MALDI-TOF and LC/MS/MS. These findings suggest that the novel functional oligo-peptides and biological activity had the potential effect to improve insulin resistance and type 2 diabetes mellitus.