Abstracts Archive

Coeliac disease is a prevalent polygenic disorder caused by a harmful immune response to cereal gluten proteins. Previously the condition was considered an inflammatory, food hypersensitivity disorder, but presence of diagnostic autoantibodies, specific killing of enterocytes and autoimmune type of ...

Proteasome is the main producer of the epitopes presented on MHC-I molecules to the CD8+ T cells. The epitopes could be produced by peptide-bond hydrolysis or by proteasome-catalysed peptide splicing (PCPS). Proteasome-generated antigenic spliced peptides seem to be much more frequent than expected....

Type 1 diabetes is an autoimmune condition in which the islets of Langerhans become infiltrated by lymphocytes which then mediate beta cell dysfunction and loss. This model has been developed mainly from studies in rodents but it is less clear whether equivalent processes occur in humans. To address...

Type 1 diabetes (T1D) occurs following a breakdown in immunological tolerance resulting in the eventual loss of functional beta cell mass. The natural history of disease includes a high degree of variability in clinical presentation between subjects with T1D. Recent studies in organ donors with T1D ...

High parameter single cell analysis has driven deep understanding of immune processes. Using a next-generation single-cell “mass cytometry” platform we quantify surface and cytokine or drug responsive indices of kinase target with 45 or more parameter analyses (e.g. 45 antibodies, viability, nuc...

As recent as a decade ago, the pathology of human diabetes had been poorly understood, predominantly because of limited access to well-preserved human pancreata. This has also hampered therapeutic progress. Through the pancreatic organ donor consortium (nPOD), we are now gaining unprecedented knowle...

Jenna Pappalardo, David van Dijk, Le Zhang, Maggie Pecsok, Smita Krishnaswamy and David A. Hafler Departments of Neurology, Immunobiology, and Genetics, Yale School of Medicine, New Haven, CT The peripheral immune system is becoming increasingly appreciated as an integral component of tissue homeost...

Multiple sclerosis (MS) is the commonest non-traumatic cause of neurological disability in young people in developed countries. There is currently no apparent cure for MS. Although the precise cause of MS remains speculative infection with EBV appears to be necessary and sufficient. In addition to E...