C-peptide Persistence in People with Type 1 Diabetes: Predictors and Consequences

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Abstract Summary

As immunoassays for C-peptide have become more sensitive it has become more apparent that many people with Type 1 diabetes have some degree of residual beta cell function. However the true extent of this across the full range of age of onset and duration of Type 1 diabetes is unclear. Neither is it clear how the genetic determinants of Type 1 diabetes or other clinical features of diabetes relate to this residual function. Whether residual beta cell function alters the clinical course of Type 1 diabetes and the incidence of acute or chronic complications is also unclear. The Scottish Diabetes Research Network Type 1 Bioresource (SDRNT1BIO) is a large (n=6127) collection of biosamples and retrospective and prospective data from a representative sample of people with Type 1 diabetes in Scotland. Participants had a clinical diagnosis of Type 1 diabetes with confirmation of insulin use within a year of onset but with no constraint on age at diagnosis. The cohort has been genotyped and random serum C-peptide (Roche ultrasensitive immunoassay) measured at recruitment. Overall 39% had detectable C-peptide (≥5 pmol/L) with prevalence being highest with older age of onset (p=6.9x10-05) and shorter duration (p=1.8x10-10). Heritability was 0.31 for age at onset and 0.26 for C-peptide adjusted for sex and age at onset. This presentation will summarise the distribution of C-peptide levels by age at onset and duration, will explore genetic associations with C-peptide levels and will summarise the relationship of C-peptide levels to complications in this cohort.

Submission ID :
IDS44265
Submission Type
Abstract Topics

Associated Sessions

University of Edinburgh

Abstracts With Same Type

13 visits

KEY DATES

Event dates:
Thursday 25 October - Monday 29 October 2018

Abstract submission deadline:
Monday 14 May 2018

Abstract notification:
July 2018

Early registration deadline:
Monday 3 September 2018

Registration deadline:
Monday 15 October 2018

Contact
British Society for Immunology
+44 (0)20 3019 5901
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