Abstracts Archive

As immunoassays for C-peptide have become more sensitive it has become more apparent that many people with Type 1 diabetes have some degree of residual beta cell function. However the true extent of this across the full range of age of onset and duration of Type 1 diabetes is unclear. Neither is it ...

A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. First, I report findings from an epigenome-wide association study in 52 monozygotic twin pairs discordant for type 1...

Immune responses to inflammation during checkpoint inhibition Ana Louisa Perdigoto MD PhD, Daniel Burkhardt PhD, Smita Krishnaswamy PhD, Nancy Kirkles-Smith, Jordan Pober MD PhD, and Kevan C. Herold, MD Autoimmune endocrinopathies are among the most common immune related adverse events following tre...

Hybrid insulin peptides (HIPs) are a new class of antigens that are targeted by autoreactive T cells isolated from the residual islets of organ donors with type 1 diabetes (T1D). Each HIP consists of a proinsulin fragment that is covalently cross-linked to another protein fragments through a peptide...

Pancreatic islets contain resident myeloid cells that include macrophages and dendritic cells, with additional monocyte recruitment following autoimmune infiltration. These CD11c-expressing myeloid populations have diverse roles in modulating the T cell response in the islets over the course of isle...

Pancreatic beta-cells are the main regulators of glucose levels in higher organisms. However, our understanding of beta-cell function comes with two caveats. First, monitoring beta-cell function with single-cell resolution in their native environment, in which beta-cells are innervated and vasculari...

Type 1 and type 2 diabetes are distinct clinical entities primarily driven by autoimmunity and metabolic dysfunction, respectively. However, there is a growing appreciation that they may share an etiopathological factor, namely the role of variation in beta-cell sensitivity to stress factors. Increa...

The cellular immune response relies upon T cell recognition of peptides presented on the cell surface in complex with HLA molecules. As such, it is the peptide cargo of these HLA molecules that dictates the quality of the immune response and ultimately the efficacy of protective immunity. Relatively...

Prior to the onset of type 1 diabetes, there is a progressive loss of self-tolerance. Continued accumulation of auto-antibodies that recognize beta cell derived proteins and the coincident or subsequent activation and activity of auto-reactive T cells lead to the destruction of pancreatic beta cell...

The physiopathology of type 1 diabetes involves deregulation of both the innate and the adaptive immune system inducing loss of self-tolerance and islet destruction. Anti-islet T cells are key effector cells in the killing of pancreatic beta cells. However beta cells also participate to their own de...

Type 1 diabetes (T1D) develops from a complex “dialogue” that is established between invading immune cells, which release a variety of chemokines and cytokines and putative immunogenic signals released by injured or dying β cells, leading to local inflammation. This dialogue is shaped by the ho...