Abstracts Archive

Loss of pancreatic islet beta cells precedes the clinical onset of autoimmune (type 1) diabetes. The prodrome can go on for months to years during which time autoantibodies against insulin (IAA), GAD65 (GADA), islet antigen-2 (IA-2A) or ZnT8 (ZnT8A) may be present alone or in various combinations. T...

Introduction: Most young children with multiple islet autoantibodies (mAabs) develop diabetes by 10 years of follow-up. Using data from several longitudinal studies of diabetes, we identified a group of slow progressors; children and adults who remain diabetes free for at least 10 years following mA...

Janelle A. Noble, PhD1, Özkan Aydemir, PhD2, Jeffrey Bailey, MD2, Åke Lernmark, PhD3, Patrick Marsh2, Agnes Andersson Svärd3, Frank Bearoff, PhD4, Elizabeth P. Blankenhorn, PhD4, and John P. Mordes, MD1,2 1Children’s Hospital Oakland Research Institute, Oakland, CA; 2Department of Medicine, Div...

Background Islet-specific autoantibodies can predict the development of type 1 diabetes. However, it remains unclear how B cells contribute to the causal pancreatic immunopathology. Furthermore, up to 30% of people positive for multiple autoantibodies will not progress to type 1 diabetes within 10 y...

  In contrast to type 1 diabetes (T1D), immune deviations in patients with organ-specific autoimmune diseases, e.g. Hashimoto’s thyroiditis (HT), Grave’s disease (GD) and Addison’s disease (AD), have not been extensively characterised. Additionally, the phenotype of peripheral blood mononucle...

Background: Type 1 diabetes (T1D) is characterised by autoimmune pancreatic beta cell destruction, resulting in insulin deficiency and hyperglycaemia. By the time of diagnosis, the autoimmune response has already destroyed many of the insulin-producing pancreatic beta cells, making it challenging t...

Prevention of type 1 diabetes (T1D) in susceptible individuals has been aimed at either boosting immunosuppressive T regulatory (Treg) or reducing autoreactive T effector (Teff) cell number and function. Low dose anti-CD3 antibody therapy has been widely used both in preclinical models of T1D and in...

Background: Before adaptive immune infiltration, inflammation and innate response remodels the islet to allow insulitis. The understanding of the cellular and molecular basis for the initial events would define new potential therapeutic targets. A single cell dissection of the very early phase of di...

Background: T-cell mitochondrial dysfunction has been linked with autoimmune disease. We have recently discovered that T-cells from T1D patients exhibit mitochondrial inner-membrane hyperpolarization and elevated proinflammatory function. We hypothesize that T-cells from patients with T1D display ab...

The role of type 17 immune responses in the pathogenesis of type 1 diabetes (T1D) has been tested in multiple studies however the importance of these pathways remains enigmatic. The function of the prototypic IL-17 family cytokine, IL-17A, has been tested most extensively and while blockade of IL-17...

Background: Type 1 diabetes (T1D) is characterized by autoimmune destruction of insulin producing β-cells. Immunotherapeutic prevention before disease onset has the best potential to preserve β-cell function, and thus, it is crucial to understand the autoimmune process leading to T1D. Although imm...

People suffered from type 2 diabetes were change in eating habits in diet. Fructose consumption increase incidence of hepatic manifestation of metabolic syndrome including insulin resistance and diabetes mellitus. In recent years, small molecular oligopeptides were used in prevention and...

Silvia Garavelli1 Mario Galgani2, Sara Bruzzaniti2, Adriana Franzese3, Enza Mozzillo3, Giuseppe Matarese2,4 and Paola de Candia1,   1Fondazione Multimedica Onlus, Milan, Italy. 2Istituto per l’Endocrinologia e l’Oncologia Sperimentale “G. Salvatore” Consiglio Nazionale delle Ricerche - Napl...

Reduction in White Blood Cell, Neutrophil and Red Blood Cell counts Related to Gender, HLA and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes Falastin Salami, Hye-Seung Lee, Eva Freyhult, Helena Elding Larsson, Åke Lernmark and Carina Törn, the TEDDY study gro...

Cell replacement therapy in type 1 diabetes (T1D) can be achieved by the transplantation of whole pancreas or pancreatic islets. Despite receiving conditioning regimen and immunosuppressive maintenance therapy, some patients show T cell-mediated allograft rejection and/or recurrence of autoimmunity...

Background: Autoimmune diabetes (T1D) is a chronic disease that causes severe loss of insulin-producing β cells in the islet. CD4 T cells have a central role in the destruction of β cells, yet the limited knowledge on the phenotype of circulating islet-reactive CD4 T cells restricts�...

Type 1 diabetes (T1D) is a chronic disease that usually presents at childhood and affects millions of individuals worldwide. T1D is caused by T cell-mediated destruction of pancreatic beta cells, leaving affected individuals reliant on life-long exogenous insulin. It is likely that blockade of patho...

Background: Autoantibodies to zinc transporter 8 (ZnT8A) are usually the last autoantibody specificity to appear in the preclinical phase of type 1 diabetes (T1D). Little is known about the factors that influence autoantibody profiles and the continuation of the autoimmune response post-diagnosis. H...

Leeana D. Peters, Joseph W. Dean, Maigan A. Brusko, Daniel J. Perry, Wen-I Yeh, and Todd M. Brusko Department of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.  IL-12 and IL-18 synergy results in the production of IFNg by T cells ...

Background: Gestational diabetes (GDM) is defined as glucose intolerance that presents during pregnancy. It increases the risk of developing diabetes later in life. Recent studies have revealed an important role of microRNAs (miRNAs) in the pathogenesis of diabetes, including GDM. However, there is ...

Background Adults with type 1 diabetes (T1D) have smaller pancreata and there is growing evidence for accompanying immune infiltrates in the exocrine pancreas and subclinical exocrine dysfunction. Beta cells comprise 200 ug/g. Conclusion Pancreatic area in transverse and longitudinal planes is redu...

Introduction Changes in the blood metabolite levels prior to the onset of T1D have been reported in only a few studies. However, reported changes have not been replicated in independent studies and the validity of the research methods has been debated in the scientific community. Therefore, we set o...

Background: Staging of preclinical type 1 diabetes (T1D) begins with the development of multiple autoantibodies (AAb). Single AAb have shown lower risk (14.5% risk of T1D within 10 years) and may result in reversion to no AAb, persistence as single AAb, or progression to 2 or more AAb. It remains un...

Background: Mitochondrial function and metabolism are fundamental for T-cell physiology and function. Upon T-cell activation genes encoding proteins that regulate mitochondrial ATP production undergo changes. Mitochondrial dysfunction in the T-cell compartment has been associated with human autoimmu...

The endothelial receptor Robo4 protects from islet inflammation during MLDS–Induced Diabetes in Mice Troullinaki Maria1, Chen Lan-sun1, Triantafyllos Chavakis1 and Antonios Chatzigeorgiou1,2 1) Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Ger...

Introduction: Nationwide epidemiological studies show that type 1 diabetes is 3 times more prevalent in major depressed patients and first degree relatives. These individuals are also more prone to infection. The NOD mouse, a classical model for type 1 diabetes, also shows an anxious behavior, which...